分类：数理化
语言：简体中文
大小：未知
发布时间：05-04-22
这两天我偶然找到了Lihninger's Principles of Biochemistry (4th edition)的原版电子书，简称POB4，PDF格式。POB4是当今世界上应用最为广泛的生物化学教材，目前已经出到第四版了。同时，POB也是考GRE Biochem Sub最重要的书，因此在中国很多高校的生物专业学生中有很高的知名度！这本书还有个配套的CD-ROM，里面有些学习这本书的软件和练习。Unfortunately，这个软件我没找到。本书英文原著是国际上公认的最权威、最受欢迎的教科书之一，被喻为“生物化学的圣经”，清华大学、北京大学等国内重点高校相关专业的老师和学生已将它作为专业入门教材。本书第1版发行于1982年。第4版不仅对各章节进行修改和重组，增加了新的内容，收入了很多全新的分子图形，而且全面概括了现代生物化学原理和技术的主要成就和最新进展。特点：（1）内容全面。（2）内容新颖。（3）书中引入了许多重要技术以阐明那些已经建立的概念和原理。新的方法主要包括NMR、质谱、 SELEX和DNA微阵列等。（4）引入了许多大分子的结构图示，总共有超过10000张的彩色图解（包括图表、照片、分子图形），强调对基本原理的阐述，有助于读者深入地了解实验方法。本书不仅适用于需要更广泛了解生物化学知识的本科生、研究生和老师，也适用于从事生命科学研究工作的广大科技人员这个PDF文件没有封面，目录也是别人另外制作的，不过正文是绝对的原版。我把第一章的第一页传上来。下面是amazon上这本书的介绍：Product DetailsList Price: 137.95 USDHardcover: 1100 pagesPublisher: W. H. Freeman; 4th edition (April 23, 2004)Language: EnglishISBN: 0716743396Product Dimensions: 11.2 x 8.8 x 1.8 inchesShipping Weight: 6.0 pounds下面是amazon上的客户评论，我选择其中之一，侧面反映了这本书的出色Superb, up to date, clear, comprehensive, February 23, 2005There basically are two top contenders for the #1 position for a biochemistry textbook: Lehninger vs Voet. At first sight, the 1650+ pages Voet text for 'chemistry' oriented students seems like it is too much for the competition. So, how can Lehninger do better in 1100 pages? There are several factors at play, and the 4th edition of Lehninger simply dominates Voet and the rest of the biochem texts out there as follows. The Lehnninger text has a long history, but given that biochemical knowledge doubles every 5 years or so, it matters what a text offers now, not in the past. The writing style is simple, direct, engaging, not too easy but neither too esoteric. The principles (as the title suggests) and the unity in diversity are emphasized, so that the student understands biochemical principles not merely facts, acronyms, pathways. The graphics are very professional. They are comparable to any review article in hot journals such as Nature, Science, Cell, etc. The rendering of protein surfaces, and the different angles through which a structure is seen is outstanding (a good example is the section on the ribosome). The structures have been rendered from the PDB (protein data bank) coordinates. Most are rendered in the ribbon representation, but in many cases the surface is rendered in grey, depending on the level of detail. Contrast this with the 3rd edition of Voet: the authors have not bothered to re-render their graphics, most are identical to the 1995 edition, a time when people only cared if you could generate a structure. Voet's graphics are not done uniformly; the backgrounds can be white, grey, black, some structures are taken directly from the original literature and vary widely in the format and rendering. It is not enough that Voet updated the text on biochemical developments from 1995-2004. The Lehninger pages on the most important protein folds, for example, are very helpful in giving the student a feel for the fold, the domain composition, the size, and names of model proteins one is expected to encounter over and again in the research literature. But pretty pictures are not the only thing that sets Lehninger apart from the rest. The material is distilled such that almost the same ammount of information is contained in this text, even though Voet is 50% bigger. There can be no such text as "Advanced Biochemistry" for grad students etc. -- if one is looking for that sort of thing, then one should purchase a life sciences encyclopedia. For undergraduates, any text is bound to be a bit overwhelming, but Lehninger is clear enough that the above average student should assimilate the material preparing for an exam without too much confusion or difficulty. I also like the typesetting in Lehninger much better than Voet, which again, uses the same boring format as the 2nd 1995 edition. The quality of paper is good in both texts. Lehninger's text feels like the space is utilized well, whereas Voet's space is a bit overcrowded, though strangely, some of the Voet structures are too large, and take up too much space. Lehninger encompases all the new developments up to 2004: RNAi, genomes, new facts on controversial enzyme mechanisms etc. Speaking of enzyme mechanism, both texts do a good job in deriving the Michaelis-Menten equation step by step rather than simply saying something like "through trivial algebra eqn 34 transforms into 45". The literature reference section of Lehninger is one of the best parts of the text: the references are a mixture of classic, outstanding work, and recent review materials, which should guide the more curious student to navigate the overwhelming ammount of information in modern biochemistry and molecular biology. I loved the numerous photos of key players in biochemistry. For example, Francis Crick is shown as a young man when the text refers to the model for DNA, and as a middle aged man in another chapter. The historical emphasis is well placed. The "working in biochemistry" boxes are similarly relevant and well placed. I only wish the current authors had added a brief sketch of Albert Lehninger. In fact, they do not mention the history of the text, which is a little strange. The text contains brief solutions to all the end-of-chapter problems so the solutions manual (unfortunately titled "The Absolute, Ultimate Guide...") is not really neccessary for the good student. I think the criticism that Voet is 'tougher' and has more 'chemistry' in it is not entirely fair. Any researcher cannot expect to find his/her answers for a particular mechanism in any textbook -- that's the whole point of research. The principles on the other hand, can be sufficiently explained with a selection of enzymes and their mechanism, which Lehninger delivers. The metabolism middle part of the book is a bit too large, but it is difficult to avoid this, as when it boils down to it, molecular biophysics and biology have to account for the behavior of a particular system. Grad students these days tend to ignore metabolism, but as they mature, they start to see its point (and the memory slowly starts to assimilate all these enzymes, substrates, products, inhibitors, conditions, pathways...). Voet, of course, also covers metabolism in a comprehensive way. In conclusion, contrary to what Voet reviewers said to "supplement Lehninger with Voet", I am suggesting students get a copy of Lehninger, either from the library or by purchasing their own copy, to supplement any biochemistry text with Lehninger. There is no other text out there that comes close to Lehninger. Which leads to the natural question, "why are there 10-20 biochem books currently in print?". Well, I certainly hope Lehninger will drive out of print most of them:-). Thank you professors Nelson and Cox for the hard and thoughtful work that went into this fourth edition....
